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KMID : 1039120140030010029
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Clinical and Experimental Vaccine Research
2014 Volume.3 No. 1 p.29 ~ p.36
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Hepatitis E virus infections in humans and animals
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Song Young-Jo
Park Woo-Jung
Park Byung-Joo
Lee Joong-Bok
Park Seung-Yong
Song Chang-Seon
Lee Nak-Hyung
Seo Kun-Ho
Kang Young-Sun
Choi In-Soo
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Abstract
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Hepatitis E has traditionally been considered an endemic disease of developing countries. It generally spreads through contaminated water. However, seroprevalence studies have shown that hepatitis E virus (HEV) infections are not uncommon in industrialized countries. In addition, the number of autochthonous hepatitis E cases in these countries is increasing. Most HEV infections in developed countries can be traced to the ingestion of contaminated raw or undercooked pork meat or sausages. Several animal species, including pigs, are known reservoirs of HEV that transmit the virus to humans. HEVs are now recognized as an emerging zoonotic agent. In this review, we describe the general characteristics of HEVs isolated from humans and animals, the risk factors for human HEV infection, and the current status of human vaccine development.
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KEYWORD
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Hepatitis E virus, Zoonoses, Animals, Humans, Vaccines
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